Targeting solute carriers to modulate receptor-ligand interactions

Hubert J Sijben; Giulio Superti-Furga; Adriaan P IJzerman; Laura H Heitman

doi:10.1016/j.tips.2022.02.004

Targeting solute carriers to modulate receptor-ligand interactions

Trends Pharmacol Sci. 2022 May;43(5):358-361. doi: 10.1016/j.tips.2022.02.004. Epub 2022 Feb 26.

Authors

Hubert J Sijben¹, Giulio Superti-Furga², Adriaan P IJzerman¹, Laura H Heitman³

Affiliations

¹ Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
² CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
³ Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands; Oncode Institute, Leiden, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.

PMID: 35232590
DOI: 10.1016/j.tips.2022.02.004

Abstract

Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of intracellular and plasma membrane receptors by ligand influx and efflux via SLCs, respectively. Here, we evaluate recent insights and provide an outlook for developing potential therapeutic strategies.

Keywords: drug discovery; receptor; solute carrier; transporter.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Cell Membrane / metabolism
Humans
Ligands
Membrane Transport Proteins* / metabolism
Solute Carrier Proteins* / metabolism

Substances

Ligands
Membrane Transport Proteins
Solute Carrier Proteins