Fluorescent probes for biomolecule detection under environmental stress

Xiaoyue Han; Yue Wang; Yan Huang; Xiaoyan Wang; Jaebum Choo; Lingxin Chen

doi:10.1016/j.jhazmat.2022.128527

Fluorescent probes for biomolecule detection under environmental stress

J Hazard Mater. 2022 Jun 5:431:128527. doi: 10.1016/j.jhazmat.2022.128527. Epub 2022 Feb 19.

Authors

Xiaoyue Han¹, Yue Wang², Yan Huang³, Xiaoyan Wang³, Jaebum Choo⁴, Lingxin Chen⁵

Affiliations

¹ CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Present: Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, UK; University of Chinese Academy of Sciences, Beijing 100049, China.
² CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
⁴ Department of Chemistry, Chung-Ang University, Seoul 06974, South Korea. Electronic address: jbchoo@cau.ac.kr.
⁵ CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Pharmacy, Binzhou Medical University, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address: lxchen@yic.ac.cn.

PMID: 35231812
DOI: 10.1016/j.jhazmat.2022.128527

Abstract

The use of fluorescent probes in visible detection has been developed over the last several decades. Biomolecules are essential in the biological processes of organisms, and their distribution and concentration are largely influenced by environmental factors. Significant advances have occurred in the applications of fluorescent probes for the detection of the dynamic localization and quantity of biomolecules during various environmental stress-induced physiological and pathological processes. Herein, we summarize representative examples of small molecule-based fluorescent probes that provide bimolecular information when the organism is under environmental stress. The discussion includes strategies for the design of smart small-molecule fluorescent probes, in addition to their applications in biomolecule imaging under environmental stresses, such as hypoxia, ischemia-reperfusion, hyperthermia/hypothermia, organic/inorganic chemical exposure, oxidative/reductive stress, high glucose stimulation, and drug treatment-induced toxicity. We believe that comprehensive insight into the beneficial applications of fluorescent probes in biomolecule detection under environmental stress should enable the further development and effective application of fluorescent probes in the biochemical and biomedical fields.

Keywords: Biomolecule; Chemical exposure; Environmental stress; Fluorescent probe; Physiological/pathological processes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorescent Dyes* / chemistry
Oxidation-Reduction

Substances

Fluorescent Dyes