A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals

Julien Olivet; Sibusiso B Maseko; Alexander N Volkov; Kourosh Salehi-Ashtiani; Kalyan Das; Michael A Calderwood; Jean-Claude Twizere; Christoph Gorgulla

doi:10.1016/j.ymthe.2022.02.015

A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals

Mol Ther. 2022 May 4;30(5):1797-1800. doi: 10.1016/j.ymthe.2022.02.015. Epub 2022 Feb 28.

Authors

Julien Olivet¹, Sibusiso B Maseko², Alexander N Volkov³, Kourosh Salehi-Ashtiani⁴, Kalyan Das⁵, Michael A Calderwood⁶, Jean-Claude Twizere⁷, Christoph Gorgulla⁸

Affiliations

¹ Structural Biology Unit, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research and Department of Microbiology, Immunology and Transplantation, Catholic University of Leuven (KU Leuven), Leuven, Belgium; Laboratory of Viral Interactomes Networks, Unit of Molecular Biology of Diseases, Interdisciplinary Cluster for Applied Genoproteomics (GIGA Institute), University of Liège, Liège, Belgium.
² Laboratory of Viral Interactomes Networks, Unit of Molecular Biology of Diseases, Interdisciplinary Cluster for Applied Genoproteomics (GIGA Institute), University of Liège, Liège, Belgium.
³ VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Brussels, Belgium; Jean Jeener NMR Centre, Free University of Brussels (VUB), Brussels, Belgium.
⁴ Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE.
⁵ Structural Biology Unit, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research and Department of Microbiology, Immunology and Transplantation, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
⁶ Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI), Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA.
⁷ Laboratory of Viral Interactomes Networks, Unit of Molecular Biology of Diseases, Interdisciplinary Cluster for Applied Genoproteomics (GIGA Institute), University of Liège, Liège, Belgium; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE; TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro Bio-tech, University of Liège, Gembloux, Belgium. Electronic address: jean-claude.twizere@uliege.be.
⁸ Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Physics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA. Electronic address: cgorgulla@g.harvard.edu.

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Antiviral Agents* / pharmacology
Antiviral Agents* / therapeutic use
Host-Pathogen Interactions
Virus Internalization*

Substances

Antiviral Agents

Publication types

MeSH terms

Substances

Grants and funding