Cardiovascular diseases (CVDs) have become the leading cause of death in China. CVDs are mainly caused by multiple well-known modifiable risk factors that are affected by socioeconomic and environmental determinants, lifestyle and behavioral choices, and familial and genetic predispositions. With more risk factors proved to be associated with CVD occurrence, the concept "pan-risk factor" is proposed in this review to indicate all discovered and yet-to-be-discovered CVD risk factors for comprehensive primary prevention of CVD. Recognizing more factors and their roles in CVD development and progression is the first step in reducing the ever-increasing burden of CVD. This review is an overview of the pan-risk factor whose associations with CVD outcomes have been established. Along with the accumulation of scientific evidence, an increasing number of risk factors will be discovered and included in the list of pan-risk factors.
在中国，心血管疾病(CVD)已成为主要的死亡原因。心血管疾病主要是由多种众所周知的可改变的危险因素引起，这些危险因素受社会经济和环境因素, 生活方式, 行为选择以及家庭和遗传易感性的影响。随着越来越多的危险因素被证实与心血管疾病的发生有关，本文提出了“泛危险因素”的概念和术语，指所有已发现和尚未发现的心血管疾病危险因素，用于心血管疾病的一级预防。认识到更多的因素及其在心血管疾病进展中的作用，是减轻日益加重的心血管疾病负担的第一步。这篇综述是对“泛危险因素”的概述，这些因素与心血管疾病预后的关系已经确定。随着科学证据的积累，越来越多的风险因素会被发现，并被列入“泛危险因素”的名单中。.
Keywords: cardiovascular diseases; primary prevention; risk factors; 一级预防; 危险因素; 心血管疾病.
© 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.