Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents

Yinghuai Zhu; Parichat Prommana; Narayan S Hosmane; Paolo Coghi; Chairat Uthaipibull; Yingjun Zhang

doi:10.1021/acsomega.1c05888

Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents

ACS Omega. 2022 Feb 9;7(7):5864-5869. doi: 10.1021/acsomega.1c05888. eCollection 2022 Feb 22.

Authors

Yinghuai Zhu¹, Parichat Prommana², Narayan S Hosmane³, Paolo Coghi⁴, Chairat Uthaipibull², Yingjun Zhang¹

Affiliations

¹ State Key Laboratory of Anti-Infective Drug Development (NO 2015DQ780357), Sunshine Lake Pharma Co., Ltd., Songshan Lake Industrial Park, Dongguan 523871, China.
² National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Pathum Thai 12120, Thailand.
³ Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
⁴ School Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau 999078, China.

Abstract

Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B _m (OH) _n ), were characterized using ¹H and ¹¹B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC₅₀ value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.