Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures

Xiao Xie; Tingting Liu; Wenqi Wang; Ge Tian; Jinyan Wang; Jitian Guan; Meng Chen; Xunchang Wang; Qingjun Zhou

doi:10.3389/fmed.2022.796667

Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures

Front Med (Lausanne). 2022 Feb 9:9:796667. doi: 10.3389/fmed.2022.796667. eCollection 2022.

Authors

Xiao Xie^{1

2

3

4}, Tingting Liu^{2

3

4

5}, Wenqi Wang^{1

2

3

4}, Ge Tian^{2

3

4

5}, Jinyan Wang^{2

3

4

5}, Jitian Guan^{2

3

4

5}, Meng Chen⁶, Xunchang Wang^{2

3

4

5}, Qingjun Zhou^{3

4

5

7}

Affiliations

¹ The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, China.
² Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China.
³ State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China.
⁴ Shandong First Medical University and Shandong Academy of Medical Sciences, Qingdao, China.
⁵ School of Ophthalmology, Shandong First Medical University, Jinan, China.
⁶ Zaozhuang Shizhong District People's Hospital, Zaozhuang, China.
⁷ Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China.

Abstract

Purpose: To observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.

Methods: Retrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Among these patients, 12 were male and 14 were female. Fifteen were monocular. The average age was 39 years. All patients underwent the following examinations: Best-corrected visual acuity (BCVA), intraocular pressure examinations, slit-lamp anterior segment examinations, indirect ophthalmoscopy, visual field examinations, fundus color photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). Some of the patients were examined with fundus fluorescein angiography (FFA). Clinical data and imaging characteristics from the OCT, OCTA, and FFA were analyzed retrospectively.

Results: We found the hyperreflective structures surrounded by hyporeflective edges around the optic discs in 37 eyes. EDI-OCT results revealed hyperreflective structures surrounded by hyporeflective edges around the optic discs in all eyes. Typical hyperreflexia lesions occurred around the optic disc, located subretinally and above Bruch's membrane. OCTA revealed that the highly reflective perioptic material also had vascular structures.

Conclusion: EDI-OCT of PHOMS showed hyperreflective structures surrounded by hyporeflective edges around all of the optic discs. Infra-red photography showed temporal hyperreflexia. These characteristics can be seen in a variety of diseases and may be a relatively common feature revealed by EDI-OCT scanning. These characteristics may also be seen in elderly patients as well as children. PHOMS may be found in optic disc drusen (ODD), tilted disc syndrome (TDS), optic neuritis, ischemic optic neuropathy, and in white dot syndromes. Few patients may be developed into macular neovascularization (MNV). In order to improve the accuracy and robustness of the conclusions and provide better clinical guidance, we need to conduct more comprehensive research in the subsequent clinical work.

Keywords: multi-mode imaging features; optic disc drusen; optic disc edema; optical coherence tomography; peripapillary hyperreflective ovoid mass-like structures; regional blood flow imaging.