Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

Risa Shimizu; Fumihiko Tsushima; Ruri Komiya; Yuko Yamagata; Hiroyuki Harada

doi:10.1159/000520534

Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

Case Rep Dermatol. 2022 Jan 10;14(1):6-11. doi: 10.1159/000520534. eCollection 2022 Jan-Apr.

Authors

Risa Shimizu¹, Fumihiko Tsushima¹, Ruri Komiya¹, Yuko Yamagata¹, Hiroyuki Harada¹

Affiliation

¹ Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

Keywords: Fixed drug eruption; Hyperpigmentation; Menstrual pain; Nonsteroidal anti-inflammatory drugs.

Publication types

Case Reports