A synthetic targeted RNA demethylation system based on CRISPR-Cas13b inhibits bladder cancer progression

Ganglin Su; Lin Yao; Xiaohong Han; Xinhui Liao; Jieqing Chen; Tao Yin; Ying Dong; Yanfeng Li; Kun Hu; Junwen Xiao; Yuchen Liu; Weiren Huang; Hongbing Mei

doi:10.1002/ctm2.734

A synthetic targeted RNA demethylation system based on CRISPR-Cas13b inhibits bladder cancer progression

Clin Transl Med. 2022 Feb;12(2):e734. doi: 10.1002/ctm2.734.

Authors

Ganglin Su^{1

2

3

4}, Lin Yao⁵, Xiaohong Han¹, Xinhui Liao¹, Jieqing Chen¹, Tao Yin^{1

3

4}, Ying Dong^{1

3

4}, Yanfeng Li^{1

3

4}, Kun Hu^{1

3

4}, Junwen Xiao^{1

3

4}, Yuchen Liu^{1

3

4}, Weiren Huang^{1

3

4}, Hongbing Mei^{1

3

4}

Affiliations

¹ Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
² Shantou University Medical College, Shantou, China.
³ Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
⁴ Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
⁵ Department of Urology, Peking University First Hospital, Beijing, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Clustered Regularly Interspaced Short Palindromic Repeats / genetics*
Clustered Regularly Interspaced Short Palindromic Repeats / physiology
DNA Demethylation*
Disease Progression
Humans
Urinary Bladder Neoplasms / genetics*
Urinary Bladder Neoplasms / metabolism
Urinary Bladder Neoplasms / physiopathology

Publication types

MeSH terms

Grants and funding