Spectral and network characterization of focal seizure types and phases

Abstract

Background and objective: Currently, epileptic seizure characterization relies on several clinical features that allow their classification into different types. The present work aims to characterize both seizure types and phases based exclusively on electrophysiological characteristics.

Methods: Based on the analysis of intracranial EEG recordings of 129 seizures from 22 patients obtained from the European Epilepsy Database, network and spectral measures were calculated in five-second temporal windows. Statistically significant differences between each window of the seizure phases (preictal, ictal, and postictal) and the interictal phase were used to identify/classify seizure types and their phases. A support vector machine (SVM) working on a multidimensional feature space of network and spectral measures was implemented for the classification of each seizure type; a traditional statistical approach was also conducted to highlight the underlying patterns to each seizure type or phase.

Results: The percentage of correct classification of seizure types, corrected by chance, provided by the SVM exceeded 70%, considering all measures and the entire seizure (preictal + ictal + postictal). This percentage increased to more than 80% when all the measures during the ictal period for the depth electrodes or during the postictal for subdural electrodes were considered. Regarding the statistical approach, several measures presented a monotonic ascending and descending behavior with respect to seizure severity; these changes were observed during the ictal and postictal periods. Some measures were specific of each seizure type.

Conclusions: Our results provide a new framework to seizure characterization and reveal the possibility of an exclusively intracranial EEG-based classification. This could be used to build an automatic seizure classification system and provides new evidence of the network-related physiopathology of epilepsies. Thus, the novelty of this work is the possibility of differentiating seizure types based exclusively on the EEG recordings, providing evidence of the underlying patterns or characteristics to each seizure type and/or phase that would allow their optimal classification.

Keywords: EEG; Epilepsy; Machine learning; Network; Seizure type.