The birth of modern chiral liquid chromatography can be traced back to the years 1968-71 when the first complete resolution of a racemic amino acid was obtained and presented in the literature. Extreme enantioselectivity was achieved due to the introduction of ligand exchange principle, i.e. participation of a copper ion in the solute-sorbent interactions. Simultaneously, first microporous (hypercrosslinked) polymeric matrixes were introduced, thus enhancing the chromatographic efficiency of the process.
Keywords: Chiral LC; Hypercrosslinked polystyrene; Ligand-exchange chromatography.
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