Effect of calorie restriction diet on levels of C reactive protein (CRP) in obesity: A systematic review and meta-analysis of randomized controlled trials

Indira Kemalasari; Nissha A Fitri; Robert Sinto; Dicky L Tahapary; Dante Saksono Harbuwono

doi:10.1016/j.dsx.2022.102388

Effect of calorie restriction diet on levels of C reactive protein (CRP) in obesity: A systematic review and meta-analysis of randomized controlled trials

Diabetes Metab Syndr. 2022 Mar;16(3):102388. doi: 10.1016/j.dsx.2022.102388. Epub 2022 Jan 5.

Authors

Indira Kemalasari¹, Nissha A Fitri², Robert Sinto³, Dicky L Tahapary⁴, Dante Saksono Harbuwono⁵

Affiliations

¹ Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Ciptomangunkusumo National General Hospital, Jakarta, Indonesia.
² Faculty of Medicine, Universitas Indonesia, Indonesia.
³ Tropical Diseases and Infections Division, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Indonesia; The Center for Clinical Epidemiology and Evidence-Based Medicine (CEEBM), Faculty of Medicine, Universitas Indonesia, Indonesia.
⁴ Division of Endocrinology and Metabolism, Internal Medicine Department, Faculty of Medicine Universitas Indonesia, Dr. Ciptomangunkusumo National General Hospital, Jakarta, Indonesia.
⁵ Division of Endocrinology and Metabolism, Internal Medicine Department, Faculty of Medicine Universitas Indonesia, Dr. Ciptomangunkusumo National General Hospital, Jakarta, Indonesia. Electronic address: dante.saksono@ui.ac.id.

PMID: 35219261
DOI: 10.1016/j.dsx.2022.102388

Abstract

Background and aims: Chronic inflammation in obese patients can be managed through a calorie-restricted diet, characterized by reduced C - reactive protein (CRP). This study aims to assess the role of such diet on CRP.

Methods: Literature searches were performed using search engines. Randomized controlled trials were included. Calorie-restricted diets in combination with non-diet interventions were excluded.

Results: Calorie restriction decreased CRP in obese patients with a mean difference of -0.22 (95% CI -0.40 to -0.04, p 0.006).

Conclusions: Calorie-restricted diet reduces CRP. Diet administration >12 weeks had a beneficial effect.

Keywords: CRP; Obesity; Restricted calorie diet.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

C-Reactive Protein* / analysis
Caloric Restriction*
Diet
Humans
Obesity
Randomized Controlled Trials as Topic

Substances

C-Reactive Protein