The Dissemination of NDM-1 in Acinetobacter baumannii Strains

Curr Microbiol. 2022 Feb 26;79(4):117. doi: 10.1007/s00284-022-02812-w.

Abstract

Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A. baumannii strains carrying NDM-1 has been climbing year by year in recent years. To characterise the transmission of NDM-1 in A. baumannii, we collected 2576 human-derived genomes of A. baumannii strains from NCBI database and found that 186 strains contained NDM-1 gene. The multi-locus sequence typing, phylogenetic tree, NDM-1 gene organization and the single nucleotide polymorphisms of NDM-1 were investigated. We hope that our work will provide a theoretical basis for the prevention of dissemination of NDM-1 in A. baumannii.

MeSH terms

  • Acinetobacter Infections*
  • Acinetobacter baumannii*
  • Anti-Bacterial Agents / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Phylogeny
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • beta-lactamase NDM-1