Mitochondrial targeted AIEgen phototheranostics for bypassing immune barrier via encumbering mitochondria functions

Pai Liu; Fei Ren; Subin Son; Myung Sun Ji; Peng Li; Zhengxu Cai; Jianbing Shi; Yi Liu; Yuping Dong; Jong Seung Kim

doi:10.1016/j.biomaterials.2022.121409

Mitochondrial targeted AIEgen phototheranostics for bypassing immune barrier via encumbering mitochondria functions

Biomaterials. 2022 Apr:283:121409. doi: 10.1016/j.biomaterials.2022.121409. Epub 2022 Feb 19.

Authors

Pai Liu¹, Fei Ren², Subin Son³, Myung Sun Ji³, Peng Li⁴, Zhengxu Cai², Jianbing Shi⁵, Yi Liu⁶, Yuping Dong², Jong Seung Kim⁷

Affiliations

¹ Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China; State Key Laboratory of Separation Membranes and Membrane Processes, School of Chemistry, Tiangong University, Tianjin 300387, China; Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.
² Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China.
³ Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.
⁴ Tianjin BHY Photoelectric Technology Co., Ltd, Tianjin, 300399, China.
⁵ Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China. Electronic address: bing@bit.edu.cn.
⁶ State Key Laboratory of Separation Membranes and Membrane Processes, School of Chemistry, Tiangong University, Tianjin 300387, China.
⁷ Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea. Electronic address: jongskim@korea.ac.kr.

PMID: 35217481
DOI: 10.1016/j.biomaterials.2022.121409

Abstract

Photodynamic therapy combined with immunogenic cell death has been proposed to overcome the unsolvable problems of single therapy, such as high levels of tumor recurrence and treatment resistance of tumors. Previous works on this theme have mostly concentrated on endoplasmic reticulum (ER)-stressed damage-associated molecular patterns (DAMPs), ignoring the secretion and function of mitochondria-related DAMPs. Herein, our work reports two intersystem crossing photosensitizers based on well-designed multiarylpyrrole structures and draws valuable attention to mitochondria-related DAMP-TFAM (mitochondrial transcription factor) when cancer cells are under forceful oxidative stress. The tumors vanished, and immunogenic experiments were applied to illuminate the advantages of double treatment. Our discovery of new mitochondria-related DAMPs compensates for the lack of ER-stressed DAMPs and offers an innovative target for immunity therapy.

Keywords: Aggregation-induced emission photosensitizers; Immune barrier; Immunogenic cell death; Mitochondria-related damage-associated molecular patterns.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endoplasmic Reticulum Stress
Humans
Mitochondria / metabolism
Neoplasms* / therapy
Photochemotherapy*
Photosensitizing Agents / metabolism
Photosensitizing Agents / pharmacology

Substances

Photosensitizing Agents