Brain-heart communication in health and diseases

Wei Liu; Xinying Zhang; Zifeng Wu; Kai Huang; Chun Yang; Ling Yang

doi:10.1016/j.brainresbull.2022.02.012

Brain-heart communication in health and diseases

Brain Res Bull. 2022 Jun 1:183:27-37. doi: 10.1016/j.brainresbull.2022.02.012. Epub 2022 Feb 22.

Authors

Wei Liu¹, Xinying Zhang², Zifeng Wu², Kai Huang¹, Chun Yang², Ling Yang³

Affiliations

¹ Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
² Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
³ Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China. Electronic address: linda_yl@sina.com.

PMID: 35217133
DOI: 10.1016/j.brainresbull.2022.02.012

Abstract

Tight connections between the brain and heart have attracted a considerable amount of attention. This review focuses on the anatomical (extrinsic cardiac autonomic nervous system and intrinsic cardiac autonomic nervous system) and functional (neuroendocrine-heart axis and neuroimmune-heart axis) connections between the brain and heart, the linkage between central nervous system diseases and cardiovascular diseases, the harm of sympathetic hyperactivity to the heart, and current neuromodulation therapies. Depression is a comorbidity of cardiovascular diseases, and the two are causally related. This review summarizes the mechanisms and treatment of depression and cardiovascular diseases, providing theoretical evidence for basic research and clinical studies to improve treatment options.

Keywords: Cardiovascular diseases; Depression; Neuromodulation therapy; Sympathetic hyperactivity; The central nervous system.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autonomic Nervous System*
Brain
Communication
Heart*