Leveraging biomaterials for enhancing T cell immunotherapy

Ziyan Liao; Wentao Zhang; Hanqi Zheng; Yanfang Wang; Jicheng Yu; Hongjun Li; Zhen Gu

doi:10.1016/j.jconrel.2022.02.023

Leveraging biomaterials for enhancing T cell immunotherapy

J Control Release. 2022 Apr:344:272-288. doi: 10.1016/j.jconrel.2022.02.023. Epub 2022 Feb 22.

Authors

Ziyan Liao¹, Wentao Zhang¹, Hanqi Zheng¹, Yanfang Wang¹, Jicheng Yu², Hongjun Li³, Zhen Gu⁴

Affiliations

¹ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
² Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.
³ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China; Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China. Electronic address: hongjun@zju.edu.cn.
⁴ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China; Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Jinhua Institute of Zhejiang University, Jinhua 321299, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: guzhen@zju.edu.cn.

PMID: 35217099
DOI: 10.1016/j.jconrel.2022.02.023

Abstract

The dynamic roles of T cells in the immune system to recognize and destroy the infected or mutated cells render T cell therapy a prospective treatment for a variety of diseases including cancer, autoimmune diseases, and allograft rejection. However, the clinical applications of T cell therapy remain unsatisfactory due to the tedious manufacturing process, off-target cytotoxicity, poor cell persistence, and associated adverse effects. To this end, various biomaterials have been introduced to enhance T cell therapy by facilitating proliferation, enhancing local enrichment, prolonging retention, and alleviating side effects. This review highlights the design strategies of biomaterials developed for T cell expansion, enrichment, and delivery as well as their corresponding therapeutic effects. The prospects of biomaterials for enhancing T cell immunotherapy are also discussed in this review.

Keywords: Biomaterials; Drug delivery; Immunotherapy; T cell delivery.

Publication types

Editorial
Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials* / therapeutic use
Humans
Immunologic Factors / therapeutic use
Immunotherapy
Neoplasms* / drug therapy
Prospective Studies
T-Lymphocytes

Substances

Biocompatible Materials
Immunologic Factors