Academ Virus, a Novel Hantavirus in the Siberian Mole (Talpa altaica) from Russia

Viruses. 2022 Feb 2;14(2):309. doi: 10.3390/v14020309.

Abstract

To date, six hantavirus species have been detected in moles (family Talpidae). In this report, we describe Academ virus (ACDV), a novel hantavirus harbored by the Siberian mole (Talpa altaica) in Western Siberia. Genetic analysis of the complete S-, M-, and partial L-genomic segments showed that ACDV shared a common evolutionary origin with Bruges virus, previously identified in the European mole (Talpa europaea), and is distantly related to other mole-borne hantaviruses. Co-evolution and local adaptation of genetic variants of hantaviruses and their hosts, with possible reassortment events, might have shaped the evolutionary history of ACDV.

Keywords: Hantaviridae; Russia; evolution; hantavirus; mole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Evolution, Molecular
  • Genome, Viral
  • Host Specificity
  • Moles / classification
  • Moles / virology*
  • Orthohantavirus / classification
  • Orthohantavirus / genetics*
  • Orthohantavirus / isolation & purification*
  • Orthohantavirus / physiology
  • Phylogeny
  • Russia