Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

Yuan Luo; Ming Lun Tseng; Sunil Vyas; Hsin Yu Kuo; Cheng Hung Chu; Mu Ku Chen; Hsiang-Chieh Lee; Wen-Pin Chen; Vin-Cent Su; Xu Shi; Hiroaki Misawa; Din Ping Tsai; Pan-Chyr Yang

doi:10.1002/smtd.202101228

Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

Small Methods. 2022 Apr;6(4):e2101228. doi: 10.1002/smtd.202101228. Epub 2022 Feb 24.

Authors

Yuan Luo^{1

2

3}, Ming Lun Tseng^{4

5}, Sunil Vyas^{1

3}, Hsin Yu Kuo^{1

3

6}, Cheng Hung Chu¹, Mu Ku Chen⁷, Hsiang-Chieh Lee⁸, Wen-Pin Chen⁹, Vin-Cent Su¹⁰, Xu Shi¹¹, Hiroaki Misawa¹¹, Din Ping Tsai^{4

6

7}, Pan-Chyr Yang^{3

12

13}

Affiliations

¹ Institute of Medical Device and Imaging, National Taiwan University, Taipei, 10051, Taiwan.
² Institute of Biomedical Engineering, National Taiwan University, Taipei, 10051, Taiwan.
³ YongLin Institute of Health, National Taiwan University, Taipei, 10672, Taiwan.
⁴ Research Center for Applied Sciences, Academia Sinica, Taipei, 11529, Taiwan.
⁵ Institute of Electronics, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
⁶ Department of Physics, National Taiwan University, Taipei, 10617, Taiwan.
⁷ Department of Electrical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China.
⁸ Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
⁹ Department and Graduate Institute of Pharmacology, National Taiwan University, Taipei, 10051, Taiwan.
¹⁰ Department of Electrical Engineering, National United University, Miaoli, 36063, Taiwan.
¹¹ Research Institute for Electronic Science Hokkaido University, Sapporo, 001-0021, Japan.
¹² Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, 10002, Taiwan.
¹³ Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

PMID: 35212186
DOI: 10.1002/smtd.202101228

Abstract

Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.

Keywords: abrupt autofocusing beam; laser surgery; metasurfaces.

MeSH terms

Animals
Lasers*
Mice
Optics and Photonics*
Swine

Abstract

MeSH terms

Grants and funding