Although proning is beneficial to acute respiratory distress syndrome, impressions vary about its efficacy. Some providers believe that paralysis is required to facilitate proning. We studied impact of paralysis on prone-induced gas exchange improvements and provider attitudes regarding paralytics.
Design: Observational.
Setting: University of California San Diego.
Patients: Intubated COVID acute respiratory distress syndrome patients.
Interventions: None.
Measurements and main results: 1) Changes in Pao2:Fio2 and Spo2:Fio2 ratios before and after proning with and without paralytics, 2) adverse events during proning with and without paralytics, and 3) nurse and physician attitudes about efficacy/safety of proning with and without paralytics. Gas-exchange improvement with proning was similar with and without paralytics (with no serious adverse events). Survey results showed similar attitudes between nurses and physicians about proning efficacy but differing attitudes about the need for paralytics with proning.
Conclusions: Findings support use of proning and may help in design of randomized trials to assess paralytics in acute respiratory distress syndrome management.
Keywords: acute respiratory distress syndrome; mechanical ventilation; neuromuscular blockade; paralytics; proning.
Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.