Stereopsis and Eye Movement Abnormalities in Parkinson's Disease and Their Clinical Implications

Fang Ba; Tina T Sang; Wenjing He; Jaleh Fatehi; Emanuel Mostofi; Bin Zheng

doi:10.3389/fnagi.2022.783773

Stereopsis and Eye Movement Abnormalities in Parkinson's Disease and Their Clinical Implications

Front Aging Neurosci. 2022 Feb 8:14:783773. doi: 10.3389/fnagi.2022.783773. eCollection 2022.

Authors

Fang Ba¹, Tina T Sang², Wenjing He³, Jaleh Fatehi¹, Emanuel Mostofi⁴, Bin Zheng³

Affiliations

¹ Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
² Faculty of Science, University of Alberta, Edmonton, AB, Canada.
³ Surgical Simulation Research Lab, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
⁴ Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Abstract

Background: Parkinson's disease (PD) is not exclusively a motor disorder. Among non-motor features, patients with PD possess sensory visual dysfunctions. Depth perception and oculomotor deficits can significantly impact patients' motor performance. Stereopsis and eye behavioral study using 3D stimuli may help determine their implications in disease status.

Objective: The objective of this study is to investigate stereopsis and eye movement abnormalities in PD with reliable tools and their correlation with indicators of PD severity. We hypothesize that patients with PD exhibit different eye behaviors and that these differences may correlate to the severity of motor symptoms and cognitive status.

Methods: Control and PD participants were first evaluated for visual acuity, visual field, contrast acuity, and stereo perception with 2D and Titmus stereotests, followed by the assessment with a 3D active shutter system. Eye movement behaviors were assessed by a Tobii X2-60 eye tracker.

Results: Screening visual tests did not reveal any differences between the PD and control groups. With the 3D active shutter system, the PD group demonstrated significantly worse stereopsis. The preserved cognitive function was correlated to a more intact stereo function. Patients with PD had longer visual response times, with a higher number of fixations and bigger saccade amplitude, suggesting fixation stabilization difficulties. Such changes showed a positive correlation with the severity of motor symptoms and a negative correlation with normal cognitive status.

Conclusion: We assessed stereopsis with a 3D active shutter system and oculomotor behaviors with the Tobii eye tracker. Patients with PD exhibit poorer stereopsis and impaired oculomotor behaviors during response time. These deficits were correlated with PD motor and cognitive status. The visual parameters may potentially serve as the clinical biomarkers for PD.

Keywords: Parkinson’s disease; biomarker; cognition; extraocular movements; stereopsis.