Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

Lisenn Lalier; François Vallette; Stéphen Manon

doi:10.3390/biom12020162

Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

Biomolecules. 2022 Jan 19;12(2):162. doi: 10.3390/biom12020162.

Authors

Lisenn Lalier^{1

2}, François Vallette^{1

2}, Stéphen Manon³

Affiliations

¹ CRCINA, Inserm, Université de Nantes, Université d'Angers, 44000 Nantes, France.
² LaBCT, Institut de Cancérologie de L'Ouest, 44800 Saint Herblain, France.
³ UMR5095, CNRS, Université de Bordeaux, 33000 Bordeaux, France.

Abstract

The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis.

Keywords: apoptosis; bcl-2 family; mitochondrial import machineries.

Publication types

Review

MeSH terms

Apoptosis Regulatory Proteins / metabolism
Carrier Proteins / metabolism
Mitochondria* / metabolism
Mitochondrial Membranes* / metabolism
Mitochondrial Proteins / metabolism
Protein Transport

Substances

Apoptosis Regulatory Proteins
Carrier Proteins
Mitochondrial Proteins