Multimodal Characterization of a PSMA-Positive Thyroid Nodule Using 68Ga-PSMA and 124Iodine PET/US Fusion Imaging

Martin Freesmeyer; Falk Gühne; Robert Drescher; Thomas Winkens; Nikolaus Gassler; Philipp Seifert

doi:10.3390/diagnostics12020472

Multimodal Characterization of a PSMA-Positive Thyroid Nodule Using ⁶⁸Ga-PSMA and ¹²⁴Iodine PET/US Fusion Imaging

Diagnostics (Basel). 2022 Feb 12;12(2):472. doi: 10.3390/diagnostics12020472.

Authors

Martin Freesmeyer¹, Falk Gühne¹, Robert Drescher¹, Thomas Winkens¹, Nikolaus Gassler², Philipp Seifert¹

Affiliations

¹ Clinic of Nuclear Medicine, Jena University Hospital, 07749 Jena, Germany.
² Section of Pathology, Institute of Forensic Medicine, Jena University Hospital, 07749 Jena, Germany.

Abstract

A 54-year-old male diagnosed with prostate cancer was referred for ⁶⁸Gallium-PSMA-11 PET/CT. The scan revealed a solitary PSMA-positive thyroid lesion. On PET/ultrasound fusion imaging, a nodule with moderate risk of malignancy (TIRADS 4B) could be unambiguously correlated. Additional ¹²⁴Iodine PET/ultrasound fusion imaging revealed normal iodine uptake within the PSMA-positive thyroid nodule. Fine-needle aspiration cytology was performed using an ultrasound needle-guidance system. The cytopathological investigation confirmed a benign thyroid nodule and excluded a thyroid carcinoma as well as a prostate cancer metastasis. Immunohistochemistry was positive for thyroglobulin staining.

Keywords: PET/US fusion imaging; PSMA; immunohistochemistry; prostate cancer; thyroid nodule.