Hemorrhagic Transformation after Intravenous Tissue Plasminogen Activator Administration in Acute Distal Middle Cerebral Artery Occlusion

Chan-Hyuk Lee; Sang Hak Yi; Byoung-Soo Shin; Hyun Goo Kang

doi:10.3390/diagnostics12020398

Hemorrhagic Transformation after Intravenous Tissue Plasminogen Activator Administration in Acute Distal Middle Cerebral Artery Occlusion

Diagnostics (Basel). 2022 Feb 3;12(2):398. doi: 10.3390/diagnostics12020398.

Authors

Chan-Hyuk Lee¹, Sang Hak Yi², Byoung-Soo Shin^{1

3}, Hyun Goo Kang^{1

3}

Affiliations

¹ Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.
² Department of Neurology, Wonkwang University School of Medicine, Iksan 54538, Korea.
³ Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.

Abstract

Atrial fibrillation and cerebral embolism are known to increase the risk of hemorrhagic transformation (HT). In addition, a sufficient number of collateral vessels in acute ischemic stroke can maintain the ischemic penumbra and prevent progression to the ischemic core, while an insufficient number of collateral vessels increase the HT risk after therapeutic recanalization. In this case, when the middle cerebral artery is recanalized, reperfusion injury may occur in the basal ganglia due to insufficient collateral vessels.

Keywords: atrial fibrillation; cerebral emboli; reperfusion injury.

Grants and funding

2020/Wonkwang University