Pindborg Tumor-An Uncommon Odontogenic Tumor Detected by 68Ga-DOTATOC

Anna Herden; Deema Sabtan; Katja Warnecke; Christian Doll; Christian Furth

doi:10.3390/diagnostics12020389

Pindborg Tumor-An Uncommon Odontogenic Tumor Detected by 68Ga-DOTATOC

Diagnostics (Basel). 2022 Feb 2;12(2):389. doi: 10.3390/diagnostics12020389.

Authors

Anna Herden¹, Deema Sabtan², Katja Warnecke³, Christian Doll⁴, Christian Furth¹

Affiliations

¹ Department of Nuclear Medicine, Chariteé-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
² Institute of Pathology, Chariteé-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Chariteéplatz 1, 10117 Berlin, Germany.
³ Departement of Internal Medicine, Rheumatology, Clinical Immunology and Osteology, Immanuel Krankenhaus Berlin-Wannsee, Koenigstrasse 63, 14109 Berlin, Germany.
⁴ Department of Oral and Maxillofacial Surgery, Chariteé-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Abstract

A 62-year-old-woman with a suspected Tumor-induced-osteomalacia (TIO), a rare neoplastic syndrome that results in renal phosphate wasting with hypophosphatemia, underwent ⁶⁸Ga-DOTATOC PET/CT on the suspicion of a mesenchymal tumor producing Fibroblast growth factor 23 (FGF23). Imaging revealed a small osteolytic, somatostatin receptor (SSTR) positive lesion containing calcifications in the alveolar process of the maxilla. No other SSTR-positive focus was found. A biopsy was performed by an oral and maxillofacial surgeon that revealed a calcifying epithelial odontogenic tumor (Pindborg tumor). This case shows that epithelial odontogenic tumors as an uncommon benign tumor entity can also be SSTR-positive.

Keywords: 68Ga-DOTATOC; Pindborg tumor; Tumor-induced-osteomalacia (TIO).