BAG Family Members as Mitophagy Regulators in Mammals

Sophie Pattingre; Andrei Turtoi

doi:10.3390/cells11040681

BAG Family Members as Mitophagy Regulators in Mammals

Cells. 2022 Feb 15;11(4):681. doi: 10.3390/cells11040681.

Authors

Sophie Pattingre¹, Andrei Turtoi¹

Affiliation

¹ Tumor Microenvironment and Resistance to Treatment Laboratory, Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, France.

Abstract

The BCL-2-associated athanogene (BAG) family is a multifunctional group of co-chaperones that are evolutionarily conserved from yeast to mammals. In addition to their common BAG domain, these proteins contain, in their sequences, many specific domains/motifs required for their various functions in cellular quality control, such as autophagy, apoptosis, and proteasomal degradation of misfolded proteins. The BAG family includes six members (BAG1 to BAG6). Recent studies reported their roles in autophagy and/or mitophagy through interaction with the autophagic machinery (LC3, Beclin 1, P62) or with the PINK1/Parkin signaling pathway. This review describes the mechanisms underlying BAG family member functions in autophagy and mitophagy and the consequences in physiopathology.

Keywords: BAG; autophagy; mitophagy; quality control.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy*
Mammals / metabolism
Mitophagy*
Molecular Chaperones* / genetics
Multigene Family
Saccharomyces cerevisiae / metabolism

Substances

Molecular Chaperones