Mitophagy in carcinogenesis and cancer treatment

Tatiana V Denisenko; Vladimir Gogvadze; Boris Zhivotovsky

doi:10.1007/s12672-021-00454-1

Mitophagy in carcinogenesis and cancer treatment

Discov Oncol. 2021 Dec 1;12(1):58. doi: 10.1007/s12672-021-00454-1.

Authors

Tatiana V Denisenko¹, Vladimir Gogvadze^{1

2}, Boris Zhivotovsky^{3

4}

Affiliations

¹ MV Lomonosov Moscow State University, 119991, Moscow, Russia.
² Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden.
³ MV Lomonosov Moscow State University, 119991, Moscow, Russia. Boris.Zhivotovsky@ki.se.
⁴ Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Boris.Zhivotovsky@ki.se.

Abstract

In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson's disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.

Keywords: Autophagy; Cancer; Homeostasis; Mitophagy.

Publication types

Review

Abstract

Publication types

Grants and funding