Human bronchial epithelial cells from patients with asthma have an altered gene expression profile

Sangita Bhaker; Michael A Portelli; Kamini Rakkar; Dominick Shaw; Simon Johnson; Christopher Brightling; Ian Sayers

doi:10.1183/23120541.00625-2021

Human bronchial epithelial cells from patients with asthma have an altered gene expression profile

ERJ Open Res. 2022 Feb 21;8(1):00625-2021. doi: 10.1183/23120541.00625-2021. eCollection 2022 Jan.

Authors

Sangita Bhaker^{1

2}, Michael A Portelli^{1

2}, Kamini Rakkar^{1

2}, Dominick Shaw¹, Simon Johnson¹, Christopher Brightling^{3

4}, Ian Sayers¹

Affiliations

¹ Translational Medical Sciences, NIHR Respiratory Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
² These authors contributed equally.
³ University of Leicester, Leicester, UK.
⁴ Dept of Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.

Abstract

Gene changes observed in asthma bronchial epithelial cells are maintained following repeated culture, presenting with an exaggerated response to viral infection and immune responses as well as having differences in the rate of cell division and replication https://bit.ly/3Cq2xKf.

Grants and funding

G1100163/MRC_/Medical Research Council/United Kingdom