Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Weijun Zhang; Jinwu Bai; Kai Hang; Jianxiang Xu; Chengwei Zhou; Lijun Li; Zhongxiang Wang; Yibo Wang; Kanbin Wang; Deting Xue

doi:10.3389/fcell.2022.817877

Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Front Cell Dev Biol. 2022 Feb 7:10:817877. doi: 10.3389/fcell.2022.817877. eCollection 2022.

Authors

Weijun Zhang^{1

2}, Jinwu Bai^{1

2}, Kai Hang^{1

2}, Jianxiang Xu^{1

2}, Chengwei Zhou^{1

2}, Lijun Li^{1

2}, Zhongxiang Wang^{1

2}, Yibo Wang^{1

2}, Kanbin Wang^{1

2}, Deting Xue^{1

2}

Affiliations

¹ Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
² Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.

Keywords: V-ATPase; lysosomal acidification; mesenchymal stem cells; pH; senescence.

Publication types

Review