Clinical Outcomes of Acellular Dermal Matrix (SimpliDerm and AlloDerm Ready-to-Use) in Immediate Breast Reconstruction

Brian P Tierney; Mauricio De La Garza; George R Jennings; Adam B Weinfeld

doi:10.7759/cureus.22371

Clinical Outcomes of Acellular Dermal Matrix (SimpliDerm and AlloDerm Ready-to-Use) in Immediate Breast Reconstruction

Cureus. 2022 Feb 18;14(2):e22371. doi: 10.7759/cureus.22371. eCollection 2022 Feb.

Authors

Brian P Tierney¹, Mauricio De La Garza², George R Jennings³, Adam B Weinfeld^{4

5}

Affiliations

¹ Plastic Surgery, Tierney Plastic and Reconstructive Surgery, Nashville, USA.
² Plastic and Reconstructive Surgery, DHR Health, McAllen, USA.
³ Plastic Surgery, Shoals Plastic Surgery Face and Body, Muscle Shoals, USA.
⁴ Surgery and Perioperative Care, Dell Medical School at the University of Texas, Austin, USA.
⁵ Plastic and Hand Surgery, Ascension Medical Group Seton, Austin, USA.

Abstract

Background The use of acellular dermal matrix (ADM) for post-mastectomy reconstruction is considered by many surgeons to be an accepted component of surgical technique. Early clinical experience is described for SimpliDerm® - a novel human ADM (Aziyo Biologics, Silver Spring, USA), and AlloDerm® Ready-To-Use (RTU) - an established ADM (Allergan Medical, Irvine, USA). Methods Records were retrospectively reviewed from four sites between 2016 and 2021 of patients who underwent immediate, two-stage reconstruction with either SimpliDerm (n=38) or AlloDerm RTU (n=69) after mastectomy and were followed out to exchange to permanent implant(s), tissue expander(s) explant, or death. Results Immediate breast reconstruction with tissue expanders and ADM was performed on 107 patients (181 breasts). Overall mean patient age was 51.4 ± 12.4 years, and mean BMI was 28.0 ± 5.8 kg/m². Significantly more patients in the SimpliDerm group were of Hispanic or Latino ethnicity (34.2% vs. 7.2%; P<.001). Reconstructions were predominantly prepectoral (82.3%). A total of 35 adverse events (AEs) occurred in 27 (25.2%) patients, with no difference in AE type, classification, or rates between ADM groups. No AEs were considered related to either ADM. The observed AE profiles and rates are similar to those published for other ADMs in immediate breast reconstruction. Conclusions There continues to be a need for additional clinically equivalent ADMs to provide physicians with more availability and options for their practice. This retrospective, multisite study describes comparable clinical outcomes with SimpliDerm and AlloDerm RTU through a median of 133.5 days (~four months) following immediate two-stage breast reconstruction.

Keywords: acellular dermal matrix; adm; alloderm; breast cancer; breast reconstruction; complications; extracellular matrix; integuply; plastic and reconstructive surgery; simpliderm.

Grants and funding

This work was supported by Aziyo Biologics, who had the following involvement with the study: design, data collection and analysis, and supported preparation of the manuscript.