The purpose of this paper is the synthesis of new metal complexes and their biological application. Four new transition metal complexes (2-5) were synthesized using conventional as well as microwave methods from 7-iminochromeno[4,3-d]pyrido[1,2-a]pyrimidin-6(7H)-one (1) and corresponding metal salts. Ligand 1 and metal complexes 2-5 were characterized by IR, 1H-NMR, 13 C-NMR, Mass spectroscopy and elemental analysis. The free ligand and the metal complexes have been tested for in vitro antiproliferative activity. The evaluation of the antiproliferative effects of compounds (1-5) on three tumor cell lines (H460, MCF-7, and HCT116) shows that all tested compounds have demonstrated moderate to pronounced antiproliferative and/or cytotoxic effect. The most active compounds were ligand 1 and metal complexes 3 and 5.
Keywords: Complexation; application; biological activity.