Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection

Signal Transduct Target Ther. 2022 Feb 21;7(1):55. doi: 10.1038/s41392-022-00911-5.

Wenhui Fan^#¹, Shanshan Sun^#², Ning Zhang^#¹, Yuan Zhang¹, Pengtao Jiao¹, Jian Wang², George F Gao^{1

3}, Wenjun Liu^{1

3}, Yuhai Bi^{4

5}, Limin Yang⁶

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
² Tianjin Speerise Challenge Biotechnology Co., Ltd, Tianjin, 300380, China.
³ University of Chinese Academy of Sciences, Beijing, 101409, China.
⁴ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. beeyh@im.ac.cn.
⁵ University of Chinese Academy of Sciences, Beijing, 101409, China. beeyh@im.ac.cn.
⁶ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. lmyang@im.ac.cn.

^# Contributed equally.

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