HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice

Qiqi Wang; Qing Chen; Yixin Zhang; Xue Zhang; Chunyu Liu; Daqi Wang; Yanhua Wu; Yixi Sun; Ling Zhang; Chengcheng Song; Yongming Wang; Yanpeng An; Huiru Tang; Congjian Xu; Yanting Wu; Li Jin; Hefeng Huang; Feng Zhang

doi:10.1002/ctm2.737

HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice

Clin Transl Med. 2022 Feb;12(2):e737. doi: 10.1002/ctm2.737.

Authors

Qiqi Wang^{1

2}, Qing Chen^{1

3}, Yixin Zhang⁴, Xue Zhang¹, Chunyu Liu^{1

2

3}, Daqi Wang¹, Yanhua Wu^{1

2}, Yixi Sun⁵, Ling Zhang^{1

3}, Chengcheng Song^{1

3}, Yongming Wang¹, Yanpeng An¹, Huiru Tang^{1

6}, Congjian Xu^{1

3}, Yanting Wu^{1

3}, Li Jin^{1

6}, Hefeng Huang^{1

3}, Feng Zhang^{1

2

3

6}

Affiliations

¹ Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction and Development, Fudan University, Shanghai, China.
² NHC Key Laboratory of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, China.
³ Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
⁴ Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁵ Department of Reproductive Genetics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁶ Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

17-Hydroxysteroid Dehydrogenases / deficiency*
Animals
Disease Models, Animal
Female
Humans
Mice
Primary Ovarian Insufficiency / etiology*

Substances

17-Hydroxysteroid Dehydrogenases
17beta-hydroxysteroid dehydrogenase type 3
HSD17B12 protein, mouse

Publication types

MeSH terms

Substances

Grants and funding