Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study

Abstract

Introduction: Blood-based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis.

Methods: Mild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large-scale longitudinal multicenter cohort, were followed-up for 3 years. A total of 165 of them converted to dementia (95% AD). Associations of conversion and plasma amyloid beta (Aβ)_1-42 , Aβ_1-40 , Aβ_1-42 /Aβ_1-40 ratio were analyzed with logistic and Cox models.

Results: Converters to dementia had lower level of plasma Aβ_1-42 (37.1 pg/mL [12.5] vs. 39.2 [11.1] , P value = .03) and lower Aβ_1-42 /Aβ_1-40 ratio than non-converters (0.148 [0.125] vs. 0.154 [0.076], P value = .02). MCI participants in the highest quartile of Aβ_1-42 /Aβ_1-40 ratio (>0.169) had a significant lower risk of conversion (hazard ratio adjusted for age, sex, education, apolipoprotein E ε4, hippocampus atrophy = 0.52 (95% confidence interval [0.31-0.86], P value = .01).

Discussion: In this large cohort of MCI subjects we identified a threshold for plasma Aβ_1-42 /Aβ_1-40 ratio that may detect patients with a low risk of conversion to dementia within 3 years.

Keywords: Alzheimer's disease; amyloid beta protein; cerebrospinal fluid; major neurocognitive disorder; mild cognitive impairment; minor neurocognitive disorder; plasma biomarkers; prognosis.