Total Laboratory Automation for Rapid Detection and Identification of Microorganisms and Their Antimicrobial Resistance Profiles

Front Cell Infect Microbiol. 2022 Feb 3:12:807668. doi: 10.3389/fcimb.2022.807668. eCollection 2022.

Abstract

At a time when diagnostic bacteriological testing procedures have become more complex and their associated costs are steadily increasing, the expected benefits of Total laboratory automation (TLA) cannot just be a simple transposition of the traditional manual procedures used to process clinical specimens. In contrast, automation should drive a fundamental change in the laboratory workflow and prompt users to reconsider all the approaches currently used in the diagnostic work-up including the accurate identification of pathogens and the antimicrobial susceptibility testing methods. This review describes the impact of TLA in the laboratory efficiency improvement, as well as a new fully automated solution for AST by disk diffusion testing, and summarizes the evidence that implementing these methods can impact clinical outcomes.

Keywords: Colibri; Copan; Radian; WASPLab artificial intelligence; WASPLab® platform; antimicrobial susceptibility testing; total laboratory automation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Automation, Laboratory* / methods
  • Drug Resistance, Bacterial
  • Laboratories

Substances

  • Anti-Bacterial Agents