Risk Analysis of Severe Thrombocytopenia in Nasopharyngeal Carcinoma During Concurrent Radio-Chemotherapy

Jialing Hu; Luoyong Tang; Yunqi Cheng; Anwen Liu; Long Huang

doi:10.3389/fonc.2021.754624

Risk Analysis of Severe Thrombocytopenia in Nasopharyngeal Carcinoma During Concurrent Radio-Chemotherapy

Front Oncol. 2022 Feb 2:11:754624. doi: 10.3389/fonc.2021.754624. eCollection 2021.

Authors

Jialing Hu¹, Luoyong Tang^{2

3}, Yunqi Cheng⁴, Anwen Liu^{2

3}, Long Huang^{2

3}

Affiliations

¹ Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
² Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
³ Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, China.
⁴ Queen Mary College, Nanchang University, Nanchang, China.

Abstract

Objective: To explore the risk factors and predictive indexes of severe thrombocytopenia during concurrent radio-chemotherapy of nasopharyngeal carcinomas.

Methods: Retrospective analysis was performed from the hospitalized patients with nasopharyngeal carcinoma from August 2014 to July 2017, and induction chemotherapy and concurrent radio-chemotherapy were completed. According to the lowest platelet count during concurrent chemotherapy, patients were divided into observation and control groups. General information and laboratory examinations were recorded and analyzed by univariate analysis, multivariate regression analysis, and ROC curve analysis.

Results: Factors, including age, PLT, IBIL, APTT at first visit, WBC, RBC, HGB, PLT, NEUT, APTT, IBIL, FFA, Crea, and urea before radio-chemotherapy, which are significant in univariate analysis into multivariate regression analysis, were taken. It turned out that RBC (OR = 10.060, 95% CI 2.679-37.777, p = 0.001), PLT (OR = 1.020, 95% CI 1.006-1.034, p = 0.005), and IBIL (OR = 0.710, 95% CI 0.561-0.898, p = 0.004) are independent predictors of severe TP in NPC. ROC analysis showed that the AUC of RBC, IBIL, PLT, and AGE is 0.746 (p < 0.001), 0.735 (p < 0.001), 0.702 (p = 0.001), and 0.734 (p < 0.001). New variables called joint predictors were calculated by a regression equation (Y = 2.309 * RBC - 0.343 * IBIL + 0.02 * PLT - 10.007), the AUC of which is 0.8700 (p < 0.001); best truncation value is >5.87 mmol/l.

Conclusions: Lower RBC, PLT, and higher IBIL before concurrent radio-chemotherapy are independent risk factors causing severe TP during concurrent radio-chemotherapy of NPC. The RBC, PLT, and IBIL before concurrent radio-chemotherapy and joint predictor have a good predictive value to evaluate the risk of severe TP during concurrent radio-chemotherapy of NPC.

Keywords: concurrent radio-chemotherapy; nasopharyngeal carcinoma; platelet depletion; predictive factors; risk factors.