Mitochondrial-Derived Peptides in Diabetes and Its Complications

Ying Wu; Liankun Sun; Zhoudao Zhuang; Xiaoqing Hu; Delu Dong

doi:10.3389/fendo.2021.808120

Mitochondrial-Derived Peptides in Diabetes and Its Complications

Front Endocrinol (Lausanne). 2022 Feb 3:12:808120. doi: 10.3389/fendo.2021.808120. eCollection 2021.

Authors

Ying Wu¹, Liankun Sun¹, Zhoudao Zhuang², Xiaoqing Hu³, Delu Dong¹

Affiliations

¹ Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China.
² Clinical Medical College of Jilin University, The First Hospital of Jilin University, Changchun, China.
³ Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China.

Abstract

The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides.

Keywords: MOTS-c; SHLPs(1-6); diabetes; humanin; mitochondrial-derived peptides (MDPs); myocardial infarction; stroke.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA, Mitochondrial / genetics
Diabetes Mellitus* / genetics
Humans
Mitochondria* / genetics
Peptides / genetics
Transcription Factors

Substances

DNA, Mitochondrial
Peptides
Transcription Factors