Differential Influence of Physical Activity on Cardiopulmonary Performance and Stroke Volume Assessed at Cardiopulmonary Exercise Test in Pectus Excavatum: A Pilot Study

Lorenzo Casatori; Alessio Pellegrino; Antonio Messineo; Marco Ghionzoli; Flavio Facchini; Alessandra Modesti; Pietro Amedeo Modesti

doi:10.3389/fphys.2022.831504

Differential Influence of Physical Activity on Cardiopulmonary Performance and Stroke Volume Assessed at Cardiopulmonary Exercise Test in Pectus Excavatum: A Pilot Study

Front Physiol. 2022 Feb 3:13:831504. doi: 10.3389/fphys.2022.831504. eCollection 2022.

Authors

Lorenzo Casatori^{1

2}, Alessio Pellegrino^{1

2}, Antonio Messineo³, Marco Ghionzoli³, Flavio Facchini³, Alessandra Modesti⁴, Pietro Amedeo Modesti^{1

2}

Affiliations

¹ Department of Clinical and Experimental Medicine, School of Medicine, University of Florence, Florence, Italy.
² Sports Medicine Unit, Careggi University Hospital, Florence, Italy.
³ Department of Pediatric Surgery, Meyer Children's University Hospital, University of Florence, Florence, Italy.
⁴ Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.

Abstract

Background: Exercise training increases muscle VO₂ by increasing O₂ transport and O₂ uptake while cardiac output increase might be limited by the conformation of the chest in subjects with pectus excavatum (PE).

Aims: The aim of the present study was to investigate the influence of physical activity (PA) on functional parameters of cardiopulmonary performance and stroke volume obtained at Cardiopulmonary Exercise Test (CPET) in PE.

Methods and procedures: A cohort of adolescents (15 with PE and 15 age- and sex-matched healthy controls, HC) underwent Cardiopulmonary Exercise Test (CPET) and administration of the International Physical Activity Questionnaire - Short Form (IPAQ-SF) with estimation of weekly PA (METs h^-1⋅week^-1). Determinants of CPET parameters were investigated with multivariable linear regression analysis.

Results: As expected, when compared to HC, PE had lower VO₂ max (37.2 ± 6.6 vs. 45.4 ± 6.4 mL⋅kg^-1⋅min^-1, p < 0.05), and VO₂/HR max (O₂ pulse, 12.1 ± 2.4 vs. 16.2 ± 3.6 mL⋅min^-1⋅bpm^-1, p < 0.05). Importantly, physical activity level was a predictor of VO₂ max (adjusted for sex, body mass index, FEV₁%, and presence of PE, β = 0.085; 95% Cl 0.010 to 0.160, p = 0.029) whereas O₂ pulse was independent from PA level (β = 0.035; 95% Cl -0.004 to 0.074).

Conclusion: Physical activity is a determinant of VO₂ max (cardiopulmonary performance), whereas it appears not to affect O₂ pulse (a measure of stroke volume at peak exercise) related to constrained diastolic filling in PE.

Keywords: O2 uptake; cardiopulmonary exercise testing; exercise training; metabolic equivalent; pectus excavatum; physical activity; stroke volume.