Rodent Lethality Models Are Problematic for Evaluating Antivenoms for Human Envenoming

Front Pharmacol. 2022 Feb 3:13:830384. doi: 10.3389/fphar.2022.830384. eCollection 2022.

Anjana Silva^{1

2

3}, Wayne C Hodgson², Theo Tasoulis⁴, Geoffrey K Isbister^{3

4}

¹ Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
² Monash Venom Group, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia.
³ South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka.
⁴ Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia.

No abstract available

Keywords: ED50; LD50; antivenom; lethality; mouse; rodent; snake venom.