Modes of Brain Cell Death Following Intracerebral Hemorrhage

Yan Zhang; Suliman Khan; Yang Liu; Ruiyi Zhang; Hongmin Li; Guofeng Wu; Zhouping Tang; Mengzhou Xue; V Wee Yong

doi:10.3389/fncel.2022.799753

Modes of Brain Cell Death Following Intracerebral Hemorrhage

Front Cell Neurosci. 2022 Feb 3:16:799753. doi: 10.3389/fncel.2022.799753. eCollection 2022.

Authors

Yan Zhang^{1

2}, Suliman Khan^{1

2}, Yang Liu^{1

2}, Ruiyi Zhang^{1

2}, Hongmin Li^{1

2}, Guofeng Wu³, Zhouping Tang⁴, Mengzhou Xue^{1

2}, V Wee Yong⁵

Affiliations

¹ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China.
³ Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
⁴ Department of Neurology, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁵ Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.

Abstract

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.

Keywords: apoptosis; autophagy; cell death; ferroptosis; intracerebral hemorrhage; necrosis; parthanatos.

Publication types

Review