Nicotinamide N-Methyltransferase in Health and Cancer

David B Ramsden; Rosemary H Waring; David J Barlow; Richard B Parsons

doi:10.1177/1178646917691739

Nicotinamide N-Methyltransferase in Health and Cancer

Int J Tryptophan Res. 2017 Jun 30:10:1178646917691739. doi: 10.1177/1178646917691739. eCollection 2017.

Authors

David B Ramsden¹, Rosemary H Waring², David J Barlow³, Richard B Parsons³

Affiliations

¹ Institute of Metabolism and Systems Research, The Medical School, University of Birmingham, Birmingham, UK.
² School of Biosciences, University of Birmingham, Birmingham, UK.
³ Institute of Pharmaceutical Science, King's College London, London, UK.

Abstract

Over the past decade, the roles of nicotinamide N-methyltransferase and its product 1-methyl nicotinamide have emerged from playing merely minor roles in phase 2 xenobiotic metabolism as actors in some of the most important scenes of human life. In this review, the structures of the gene, messenger RNA, and protein are discussed, together with the role of the enzyme in many of the common cancers that afflict people today.

Keywords: Energy metabolism; cancer; fat; liver.

Publication types

Review