Knockdown of miR-92a suppresses the stemness of colorectal cancer cells via mediating SOCS3

Lifa Li; Jingxiao Zhang; Hong Peng; Xianhong Jiang; Zuoliang Liu; Hongpeng Tian; Songlin Hou; Xingjiang Xie; Qiang Peng; Tong Zhou

doi:10.1080/21655979.2021.2022267

Knockdown of miR-92a suppresses the stemness of colorectal cancer cells via mediating SOCS3

Bioengineered. 2022 Mar;13(3):5613-5624. doi: 10.1080/21655979.2021.2022267.

Authors

Lifa Li¹, Jingxiao Zhang², Hong Peng³, Xianhong Jiang¹, Zuoliang Liu¹, Hongpeng Tian¹, Songlin Hou¹, Xingjiang Xie¹, Qiang Peng¹, Tong Zhou^{4

5}

Affiliations

¹ Department of Gastrointestinal Surgery II, Hepatobiliary and Pancreatic Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
² Department of Medica, The Second Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
³ Department of Anorectal Surgery, Nanchong Central Hospital, the Second Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China.
⁴ Department of Gastrointestinal Surgery II, The Second Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
⁵ Department of Gastrointestinal Surgery II, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.

Abstract

CRC, cancer cell; CSCs, cancer stem cells; SOCS3, suppressor of cytokine signaling 3.

Keywords: Colorectal cancer; cancer stem cell; miR-92a; proliferation; self-renewal; socs3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms* / genetics
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / genetics
Suppressor of Cytokine Signaling 3 Protein* / genetics
Suppressor of Cytokine Signaling 3 Protein* / metabolism

Substances

MIRN92 microRNA, human
MicroRNAs
SOCS3 protein, human
Suppressor of Cytokine Signaling 3 Protein

Grants and funding

This research was financially supported by the University cooperative research projects (North sichuan Medical college) (No. 18SXHZ0548, No. 18SXHZ0511) and School-level scientific research development project (No. CBY17-A-ZD06).