Objective: To explore the distribution patterns of cardiometabolic diseases (CMD) in elderly patients with colorectal cancer, and provide a reference for the prevention and treatment of cardiovascular metabolic diseases in these patients. Methods: Clinical data of 3 894 elderly patients with colorectal cancer from January 2008 to March 2018 admitted in the Chinese PLA General Hospital were recruited and the incidence rate of CMD was retrospectively analyzed. The influence factors of elderly patients with colorectal cancer combined with CMD were analyzed by multivariate Logistic regression model. Results: The morbidity rate of CMD in elderly patients with colorectal cancer is 33.4% (1 301/3 894), among them, the morbidity rate of the male was 31.9% (768/2 409), and that of the female was 35.9% (533/1 485). There was not significant difference between these two sex (P=0.074). The morbidity rates of CMD in patients of 65-74 years, 75-84 years and ≥85 years were 30.6% (754/2 462), 37.0% (479/1 294) and 49.3% (68/138), respectively, with significant differences (P<0.001). Multiple Logistic regression analysis revealed that female (OR=1.213, 95%CI: 1.056-1.394), age (75-84 years group: OR=1.344, 95%CI: 1.164-1.552; ≥85 years group: OR=2.345, 95%CI: 1.651-3.331) and body mass index (BMI 18.5-24.9 kg/m(2) group: OR=1.319, 95%CI: 1.065-1.638; ≥25 kg/m(2) group: OR=2.041, 95%CI: 1.627-2.561) were independent risk factors for elderly colorectal cancer patients with CMD. Conclusion: The morbidity rate of CMD in elderly patients with colorectal cancer increases with age and it is urgent to strengthen multidisciplinary cooperation and develop reasonable treatment plans to extend the survival and life quality of these patients.
目的： 探讨老年结直肠癌患者心血管代谢性疾病(CMD)的患病情况，为老年结直肠癌患者CMD的防治提供参考。 方法： 收集3 894例2008年1月—2018年3月解放军总医院住院老年结直肠癌患者的临床资料，回顾性分析其CMD患病率，采用多因素Logistic回归模型分析老年结直肠癌患者合并CMD的影响因素。 结果： 老年结直肠癌患者CMD患病率为33.4%(1 301/3 894)，其中男性患者的CMD患病率为31.9%(768/2 409)，女性患者的CMD患病率为35.9%(533/1 485)，不同性别老年结直肠癌患者的CMD患病率差异无统计学意义(P＝0.074)。在65~74岁组患者中，CMD患病率为30.6%(754/2 462)；在75~84岁组患者中，CMD患病率为37.0%(479/1 294)；在≥85岁组患者中，CMD患病率为49.3%(68/138)。不同年龄组老年结直肠癌患者的CMD患病率差异有统计学意义(P<0.001)。多因素Logistic回归分析显示，性别(女性：OR＝1.213，95%CI为1.056~1.394)、年龄(75~84岁：OR＝1.344，95%CI为1.164~1.552；≥85岁：OR＝2.345，95%CI为1.651~3.331)、BMI(18.5~24.9 kg/m(2)：OR＝1.319，95% CI为1.065~1.635；≥25 kg/m(2)：OR＝2.041，95%CI为1.627~2.561)是老年结直肠癌患者CMD患病的独立影响因素。 结论： 老年结直肠癌患者的CMD患病率随年龄增加而增高。在老年结直肠癌患者的临床治疗过程中，亟需加强相关学科的合作，以延长老年结直肠癌患者的生存时间，提高老年结直肠癌患者的生活质量。.
Keywords: Aged; Cardiometabolic disease; Colorectal neoplasms.