Effect of an exclusive human milk diet on feeding tolerance in preterm infants

J Perinatol. 2022 Aug;42(8):1070-1075. doi: 10.1038/s41372-022-01348-y. Epub 2022 Feb 18.

Abstract

Objective: To compare the time to full enteral feeds in preterm infants fed exclusive human milk (EHM) - mother's own milk (MOM) fortified with human milk-based fortifier (HMBF), to those who received partial human milk (PHM) - MOM fortified with bovine milk-based fortifier (BMBF), and exclusive formula.

Study design: A single-center retrospective study of infants with birth weight <1250 g from 2013 to 2018. Data on feeding, growth and other short-term neonatal morbidities were collected.

Results: On regression analysis, time to full enteral feeds was significantly higher in PHM compared to EHM group (β-coefficient 4.14, 95% CI 0.00-8.29) and formula-fed group compared to EHM (β-coefficient 4.3, 95% CI 0.32-8.20). No significant differences in growth velocity, length of stay and other morbidities were found between the groups.

Conclusion: Infants in EHM had better feeding tolerance and reached their enteral feed goals sooner compared to PHM and formula-fed groups.

MeSH terms

  • Diet
  • Food, Fortified
  • Humans
  • Infant
  • Infant Formula
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Very Low Birth Weight
  • Milk, Human*
  • Retrospective Studies