Meta-analysis of sleep deprivation effects on depression in rodents

Baiqi Hu; Chunyan Liu; Tingting Lv; Fangyi Luo; Chao Qian; Jian Zhang; Mengfei Ye; Zheng Liu

doi:10.1016/j.brainres.2022.147841

Meta-analysis of sleep deprivation effects on depression in rodents

Brain Res. 2022 May 1:1782:147841. doi: 10.1016/j.brainres.2022.147841. Epub 2022 Feb 17.

Authors

Baiqi Hu¹, Chunyan Liu², Tingting Lv³, Fangyi Luo³, Chao Qian⁴, Jian Zhang³, Mengfei Ye⁵, Zheng Liu⁶

Affiliations

¹ Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China; Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang 312000, China; Department of Neurology, Shaoxing Hospital, China Medical University, Shaoxing, Zhejiang, China.
² Department of Orthopedics, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
³ Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang 312000, China.
⁴ Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China.
⁵ Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China; Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang 312000, China. Electronic address: mengfeiye1107@163.com.
⁶ Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang 312000, China. Electronic address: liuzheng1202@usx.edu.cn.

PMID: 35183523
DOI: 10.1016/j.brainres.2022.147841

Abstract

Objective: To our knowledge, the relationship of sleep deprivation (SD) and depression on the rodents remains unclear. In this article, we performed a meta-analysis to provide a comprehensive evaluation of the experimental effects of SD on rodents and explore the heterogeneous factors that may be associated with outcomes.

Methods: PubMed, Embase, the Cochrane Library, and Web of Science were searched for articles before January 5th, 2022. The strains of rodents, SD method, and depression measurement tools were recorded. Standardized mean differences based on Hedge's g were calculated as measures of the effect size.

Results: In total, 19 studies involving 51 trials were included. The overall data suggested that SD had a large effect on exacerbating depression-like behaviors, but there was high heterogeneity [-1.09 (-1.57, -0.62); I² = 90.3%; P < 0.05]. Subgroup analysis showed that tail suspension test better reflected the effect of SD in exacerbating depression-like behavior [-3.677 (-4.758, -2.597); I² = 56.7%; P = 0.001] than forced swimming test [-0.821 (-1.439, -0.203); I² = 91%; P = 0.009] and sucrose preference test [-1.033 (-1.709, -0.358); I² = 81.6%; P = 0.003].

Conclusion: This study found that SD worsened depression-like behaviors by tail suspension test. Our results also indicated that the effects of SD on depression in rodents were related to different assessment methods, strains, SD methods and SD types.

Keywords: Depression; Forced swimming test; Meta-analysis; Rodents; Sleep deprivation; Sucrose preference test; Tail suspension test.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Depression*
Hindlimb Suspension
Rodentia
Sleep Deprivation* / complications
Swimming