Multiple roles of apelin/APJ system in eye diseases

Jingshun Luo; Qun Zhao; Zhiyue Li; Linxi Chen

doi:10.1016/j.peptides.2022.170767

Multiple roles of apelin/APJ system in eye diseases

Peptides. 2022 Jun:152:170767. doi: 10.1016/j.peptides.2022.170767. Epub 2022 Feb 15.

Authors

Jingshun Luo¹, Qun Zhao², Zhiyue Li³, Linxi Chen⁴

Affiliations

¹ Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
² Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Department of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: lizhiyuecs@163.com.
⁴ Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. Electronic address: 1995001765@usc.edu.cn.

PMID: 35181348
DOI: 10.1016/j.peptides.2022.170767

Abstract

Apelin is an endogenous ligand of G protein-coupled receptor (APJ), and they compose apelin/APJ system. Apelin/APJ system is widely distributed in tissues and plays pleiotropic roles. Attractively, more emphasis has recently been placed on the effects of apelin/APJ system in eye diseases, such as retinopathy of prematurity (ROP), diabetic retinopathy (DR) and diabetic macular edema (DME). In this review, we elaborated the roles of apelin/APJ system in the pathophysiological processes of eye. Concretely, apelin/APJ system induces retinal gliosis and angiogenesis. Hypoxia-inducible factors (HIFs) are involved in apelin/APJ system-triggered ROP progress. Apelin/APJ system mediates DR-induced retinopathy. Apelin/APJ system maintains retinal functions and health by protecting Müller cells from apoptosis. Apelin/APJ system suppresses the NMDA-induced retinal ganglion cell (RGC) loss to protect optic nerve damage. Overall, apelin/APJ system is a potential therapeutic target for eye disease.

Keywords: Apelin/APJ system; Diabetic retinopathy; Ophthalmology; Retinal angiogenesis; Retinopathy of prematurity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apelin / genetics
Apelin Receptors / genetics
Diabetic Retinopathy* / genetics
Humans
Infant, Newborn
Macular Edema*
Receptors, G-Protein-Coupled / genetics

Substances

Apelin
Apelin Receptors
Receptors, G-Protein-Coupled