A tipping point in cancer epidemiology: embracing a life course exposomic framework

Rosalind J Wright; Heidi A Hanson

doi:10.1016/j.trecan.2022.01.016

A tipping point in cancer epidemiology: embracing a life course exposomic framework

Trends Cancer. 2022 Apr;8(4):280-282. doi: 10.1016/j.trecan.2022.01.016. Epub 2022 Feb 16.

Authors

Rosalind J Wright¹, Heidi A Hanson²

Affiliations

¹ Department of Environmental Medicine and Public Health, New York, NY, USA; Institute for Exposomic Research, New York, NY, USA. Electronic address: rosalind.wright@mssm.edu.
² Computational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA; Department of Surgery, University of Utah, Salt Lake City, UT, USA.

PMID: 35181274
DOI: 10.1016/j.trecan.2022.01.016

Abstract

The pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.

Keywords: air pollution; carcinogens; exposome; life course theory; pediatric cancer; radon.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Environmental Exposure / adverse effects
Humans
Life Change Events*
Neoplasms* / etiology
Neoplasms* / genetics

Abstract

Publication types

MeSH terms

Grants and funding