Protein markers of primary salivary gland tumors: A systematic review of proteomic profiling studies

Reydson Alcides de Lima-Souza; João Figueira Scarini; Luccas Lavareze; Carolina Emerick; Erison Santana Dos Santos; Adriana Franco Paes Leme; Erika Said Abu Egal; Albina Altemani; Fernanda Viviane Mariano

doi:10.1016/j.archoralbio.2022.105373

Protein markers of primary salivary gland tumors: A systematic review of proteomic profiling studies

Arch Oral Biol. 2022 Apr:136:105373. doi: 10.1016/j.archoralbio.2022.105373. Epub 2022 Feb 10.

Authors

Reydson Alcides de Lima-Souza¹, João Figueira Scarini¹, Luccas Lavareze¹, Carolina Emerick¹, Erison Santana Dos Santos², Adriana Franco Paes Leme³, Erika Said Abu Egal⁴, Albina Altemani⁵, Fernanda Viviane Mariano⁶

Affiliations

¹ Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
² Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil; Laboratory of Mass Spectrometry, Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
³ Laboratory of Mass Spectrometry, Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
⁴ Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Department of Pathology, School of Medicine, University of Utah (UU), Salt Lake City, UT, United States.
⁵ Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
⁶ Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address: fmariano@unicamp.br.

PMID: 35180549
DOI: 10.1016/j.archoralbio.2022.105373

Abstract

Objective: To integrate all the available data published in the English literature regarding the protein diagnostic and/or prognostic markers in salivary gland tumors identified by mass spectrometry (MS)-based discovery proteomics.

Design: An extensive search was carried out using MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases. Manual searching in Google Scholar and assessment of the reference list of the included articles also was performed. The risk of bias was assessed by the Joanna Briggs Institute Critical Appraisal tool for the specific type of study.

Results: A total of 1092 articles were initially retrieved within which 6 were used for data extraction, resulting in 145 cases of salivary gland tumors. The data was composted by eleven salivary gland tumor types. In total, 2136 proteins were detected by MS-based discovery proteomics in salivary gland tumors. Ninety-one proteins were proposed as potential diagnostic and/or prognostic markers. Of these, some have been identified in one or more studies, whereas fifteen were in common across studies and a total of seventy-six were non-repeat proteins.

Conclusion: In summary, we compiled data about the proteomic profile of potential diagnostic and/or prognostic protein markers of the salivary gland tumors detected by MS-based discovery proteomics. The proteins ANXA1, ANXA5, CAPG, CRYAB, FGB, GNB2L1, IGHG1, PPIA, S100A9, and SOD1 were proposed as the most common potential diagnostic markers of salivary gland tumors.

Keywords: Biomarkers; Mass spectrometry; Proteomics; Salivary gland neoplasms; Systematic review.

Publication types

Review
Systematic Review

MeSH terms

Annexin A5
Biomarkers
Humans
Mass Spectrometry
Proteomics*
Salivary Gland Neoplasms* / diagnosis

Substances

Annexin A5
Biomarkers