Topographical Relationship Between Acute Macular Neuroretinopathy and Choroidal Watershed Zone or Patchy Choroidal Filling

Jialiang Duan; Jianbin An; Minhao Li; Zhengwei Zhang; Liang Zhou; Pengfei Yin; Jingxue Ma; Qingli Shang

doi:10.3389/fmed.2022.762609

Topographical Relationship Between Acute Macular Neuroretinopathy and Choroidal Watershed Zone or Patchy Choroidal Filling

Front Med (Lausanne). 2022 Feb 1:9:762609. doi: 10.3389/fmed.2022.762609. eCollection 2022.

Authors

Jialiang Duan¹, Jianbin An¹, Minhao Li¹, Zhengwei Zhang², Liang Zhou³, Pengfei Yin⁴, Jingxue Ma¹, Qingli Shang¹

Affiliations

¹ Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
² Department of Ophthalmology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
³ Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China.
⁴ Department of Ophthalmology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.

Abstract

Purpose: To study the topographical relationship between acute macular neuroretinopathy (AMN) lesions and the choroidal watershed zone (CWZ) or patchy choroidal filling (PCF) using multimodal imaging.

Methods: Lesions in patients diagnosed with AMN were clinically examined using multimodal imaging, including fundus photography, near-infrared reflectance imaging, spectral-domain optical coherence tomography (OCT), fluorescein angiography, indocyanine green angiography, OCT angiography, and microperimetry. The topographical relationship between AMN and the CWZ or PCF was evaluated.

Results: Seven eyes of six patients were included in the study. The mean age of the patients was 35.8 ± 11.7 years. The AMN lesions were collocated with the CWZ in five eyes and the PCF in one eye. Among these eyes, three had complete patterns, and three had partial patterns. Only one eye showed no topographical relationship between AMN and the CWZ or PCF.

Conclusion: The colocation of AMN and CWZ/PCF suggests that the AMN lesions were within an area with a dual-watershed zone: the watershed zone between the retinal deep capillary plexus and choriocapillaris, and the choroidal watershed zone or patchy choroidal filling. This retinal area was highly vulnerable to hypoperfusion. Our results suggest a novel pathophysiological mechanism for AMN.

Keywords: acute macular neuroretinopathy (AMN); choroidal watershed zone; indocyanine green angiography (ICGA); near-infrared reflectance imaging; patchy choroidal filling.