Oreocharioside A-G, new acylated C-glycosylflavones from Oreocharis auricula (Gesneriaceae)

Rui-Xuan Xie; Jun-Lei Chen; Li-Qiang Zhou; Xian-Jie Fu; Chun-Mao Yuan; Zhan-Xing Hu; Lie-Jun Huang; Xiao-Jiang Hao; Wei Gu

doi:10.1016/j.fitote.2022.105158

Oreocharioside A-G, new acylated C-glycosylflavones from Oreocharis auricula (Gesneriaceae)

Fitoterapia. 2022 Apr:158:105158. doi: 10.1016/j.fitote.2022.105158. Epub 2022 Feb 14.

Authors

Rui-Xuan Xie¹, Jun-Lei Chen², Li-Qiang Zhou², Xian-Jie Fu², Chun-Mao Yuan², Zhan-Xing Hu², Lie-Jun Huang², Xiao-Jiang Hao³, Wei Gu⁴

Affiliations

¹ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of pharmaceutical Sciences, Guizhou Medical University, Guiyang 550014, China.
² State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
³ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: haoxj@mail.kib.ac.cn.
⁴ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China. Electronic address: guwei2009@126.com.

PMID: 35176424
DOI: 10.1016/j.fitote.2022.105158

Abstract

Seven new acylated C-glycosylflavones, oreocharioside A-G, together with two known compounds were isolated from the whole plant of Oreocharis auricula. Their structures were characterized by the comprehensive analysis of their NMR, IR, UV, CD spectra and HRESIMS data. All the new compounds were evaluated for the antioxidant and anti-inflammatory activities. The results showed that compounds 1 and 2 had significant DPPH and ABTS radical scavenging activities, with the IC₅₀ values of 0.32-3.20 μg/mL. Compounds 2 and 3 exhibited the higher potency among all the new compounds in reducing TNF-α production.

Keywords: Acylated C-glycosylflavones; Anti-inflammatory activity; Antioxidant activity; Oreocharis auricula.

MeSH terms

Anti-Inflammatory Agents* / pharmacology
Antioxidants* / chemistry
Molecular Structure
Plant Extracts / chemistry

Substances

Anti-Inflammatory Agents
Antioxidants
Plant Extracts