Abstract
Low levels of immune infiltrates in the tumor milieu hinder the effectiveness of immunotherapy against immune-cold tumors. In the current work, a tumor-targeting drug delivery system composed of Endo-loaded platelets (Endo@PLT) was developed to relieve immunosuppression by achieving tumor vascular normalization. Endo@PLT reprogrammed the immunostimulatory phenotype, achieving excellent PD-1 immunotherapy in vivo.
MeSH terms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Humans
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Immunosuppression Therapy
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Immunotherapy
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Mice
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Mice, Inbred C57BL
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Neoplasms / immunology*
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Neoplasms / therapy
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Neoplasms, Experimental / immunology
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Neoplasms, Experimental / therapy
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Neovascularization, Pathologic / immunology*
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Neovascularization, Pathologic / therapy
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / immunology*