Changes in humoral immunity, myocardial damage, trace elements, and inflammatory factor levels in children with rotavirus enteritis

Peihui Liu; Rong Zou; Jie Zhao; Jindou Hao; Yongmei Zeng; Wanqu Liu; Jia Tian; Hao Wang

Changes in humoral immunity, myocardial damage, trace elements, and inflammatory factor levels in children with rotavirus enteritis

Am J Transl Res. 2022 Jan 15;14(1):452-459. eCollection 2022.

Authors

Peihui Liu¹, Rong Zou², Jie Zhao³, Jindou Hao¹, Yongmei Zeng¹, Wanqu Liu¹, Jia Tian¹, Hao Wang⁴

Affiliations

¹ Department of Pediatrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University Shenzhen City, Guangdong Province, China.
² Department of Pharmacy, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University Shenzhen City, Guangdong Province, China.
³ Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University Shenzhen City, Guangdong Province, China.
⁴ Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University Shenzhen City, Guangdong Province, China.

PMID: 35173864
PMCID: PMC8829652

Abstract

Objective: To investigate the changes and significance of humoral immunity, myocardial damage, trace elements and inflammatory factors levels in children with rotavirus enteritis.

Methods: One hundred children with rotavirus enteritis admitted to our hospital from January 2019 to December 2020 were retrospectively selected as the case group, and they were divided into a no dehydration group (33 cases), mild dehydration group (41 cases), and moderate dehydration group (26 cases). Another 100 children with rotavirus-negative enteritis during the same period were selected as the control group. Serum immunoglobulin, cardiac enzyme profile, trace elements, and interleukin-6 (IL-6) levels were compared between the two groups, and among the case groups for different degrees of dehydration.

Results: Serum immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), zinc, magnesium, and calcium in the case group were lower than in controls (P<0.05). Serum lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB) in the case group were higher than in controls (P<0.05). Serum IL-6, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) were also higher in cases than controls (P<0.05). Serum IgA, IgG, IgM, zinc, magnesium, and calcium in children with rotavirus enteritis with mild dehydration were lower than those without dehydration, but higher than those with moderate dehydration (P<0.05). Serum LDH, α-HBDH, CK, and CK-MB in children with rotavirus enteritis with mild dehydration were higher than those without dehydration, but lower than those with moderate dehydration (P<0.05). Serum IL-6, IL-8, and TNF-α in children with rotavirus enteritis with mild dehydration were higher than those without dehydration, but lower than those with moderate dehydration (P<0.05).

Conclusion: Children with rotavirus enteritis with more severe dehydration exhibited lower levels of humoral immunity and trace elements and greater myocardial damage and inflammatory response. Early detection can accurately assess the condition and provide a reference for clinical treatment.

Keywords: Rotavirus enteritis; humoral immunity; inflammatory factors; myocardial damage; trace elements.